Indigenous health in PCOS
Project Lead: Dr Jacqueline Boyle and Dr Michael Davies
This research is generating novel community-based natural history data on PCOS, exploring complications, prevalence, treatments, consequences and the role of obesity. Most women with PCOS who need fertility treatment use ovulation induction, involving clomiphene citrate, aromatase inhibitors, metformin and follicle stimulating hormone (FSH); but there are concerns about their safety. We will perform unique data linkage studies between relevant prescriptions on the Pharmaceutical Benefits Scheme and perinatal outcomes, congenital abnormalities and will interrogate national birth data, our cohorts and newly established registries to establish clinical efficacy and safety.
Project Lead: Professor Michael Davies
There are higher rates and severity of depression and anxiety in PCOS and reduced quality of life (QoL). By bringing in psychological expertise, we will refine the PCOS QoL tool, prospectively collect mood and QoL data across the lifespan and generate new knowledge on anxiety, depression, eating disorders, sexual function and body image in PCOS. We will study interactions with infertility and obesity, both with potential to exacerbate mood disorders. We will have new opportunities to study psychological health and QoL in Indigenous populations with PCOS through health-services research and new models of care.
Project Lead: Professor Jane Speight