Understanding and changing fertility management
The impact of environmental factors and particularly obesity, on animal ovary and egg function is being studied using dietary manipulation, gene-knockout mice and examination of egg-cumulus complexes. IVF in PCOS has high complication rates, with risk of life-threatening ovarian hyper-stimulation syndrome due to sensitivity to FSH. In new clinical research, we will link our science and clinical groups to expand experimental in vitro egg maturation in PCOS. We will establish different fertility treatment regimens, aiming to limit drug stimulation in infertility treatment. New research will optimise repair of affected eggs in PCOS, both in vivo and in vitro and develop radically new low-dose IVF regimens with reduced risks and costs.
Project Lead: Professor Roger Hart